The runaway instability of thick discs around black holes. I. The constant angular momentum case

We present results from a numerical study of the runaway instability of thick discs around black holes. This instability is an important issue for most models of cosmic gamma-ray bursts, where the central engine responsible for the initial energy release is such a system consisting of a thick disc surrounding a black hole. We have carried out a comprehensive number of time-dependent simulations aimed at exploring the appearance of the instability. Our study has been performed using a fully relativistic hydrodynamics code. The general relativistic hydrodynamic equations are formulated as a hyperbolic flux-conservative system and solved using a suitable Godunov-type scheme. We build a series of constant angular momentum discs around a Schwarzschild black hole. Furthermore, the self-gravity of the disc is neglected and the evolution of the central black hole is assumed to be that of a sequence of exact Schwarzschild black holes of varying mass. The black hole mass increase is thus determined by the mass accretion rate across the event horizon. In agreement with previous studies based on stationary models, we find that by allowing the mass of the black hole to grow the disc becomes unstable. Our hydrodynamical simulations show that for all disc-to-hole mass ratios considered (between 1 and 0.05), the runaway instability appears very fast on a dynamical timescale of a few orbital periods, typically a few 10 ms and never exceeding 1 s for our particular choice of the mass of the black hole ($2.5 \mathrm{M_\odot}$) and a large range of mass fluxes (\dot{m} \ga 10^{-3} \mathrm{M_{\odot}/s}). The implications of our results in the context of gamma-ray bursts are briefly discussed.Comment: 20 pages, 16 figures, to appear in MNRA

Freesound Explorer: Make Music While Discovering Freesound!

Freesound Explorer is a visual interface for exploring Freesound content in a two-dimensional space and creating music by linking content in that space. Freesound Explorer is implemented as a web application which takes advantage of modern web technologies including the Web Audio API and the Web MIDI API. This extended abstract describes Freesound Explorer’s features and provides some technical details about its implementation

FSD50K: an Open Dataset of Human-Labeled Sound Events

Most existing datasets for sound event recognition (SER) are relatively small and/or domain-specific, with the exception of AudioSet, based on a massive amount of audio tracks from YouTube videos and encompassing over 500 classes of everyday sounds. However, AudioSet is not an open dataset---its release consists of pre-computed audio features (instead of waveforms), which limits the adoption of some SER methods. Downloading the original audio tracks is also problematic due to constituent YouTube videos gradually disappearing and usage rights issues, which casts doubts over the suitability of this resource for systems' benchmarking. To provide an alternative benchmark dataset and thus foster SER research, we introduce FSD50K, an open dataset containing over 51k audio clips totalling over 100h of audio manually labeled using 200 classes drawn from the AudioSet Ontology. The audio clips are licensed under Creative Commons licenses, making the dataset freely distributable (including waveforms). We provide a detailed description of the FSD50K creation process, tailored to the particularities of Freesound data, including challenges encountered and solutions adopted. We include a comprehensive dataset characterization along with discussion of limitations and key factors to allow its audio-informed usage. Finally, we conduct sound event classification experiments to provide baseline systems as well as insight on the main factors to consider when splitting Freesound audio data for SER. Our goal is to develop a dataset to be widely adopted by the community as a new open benchmark for SER research

Increased ROS Production: A Component of the Longevity Equation in the Male Mygalomorph, Brachypelma albopilosa

The diversity of longevities encountered in wildlife is one of the most intriguing problems in biology. Evolutionary biologists have proposed different theories to explain how longevity variability may be driven by bad genes expression in late life or by gene pleiotropic effects. This reflexion has stimulated, in the last ten years, an active research on the proximal mechanisms that can shape lifespan. Reactive oxygen species (ROS), i.e., the by-products of oxidative metabolism, have emerged as the main proximate cause of ageing. Because ROS are mainly produced by the mitochondria, their production is linked to metabolic rate, and this may explain the differences in longevity between large and small species. However, their implication in the sex difference in longevity within a species has never been tested, despite the fact that these differences are widespread in the animal kingdom.Mitochondrial superoxide production of hemolymph immune cells and antioxidant and oxidative damages plasma levels were measured in adult male and female B. albopilosa at different ages. We found that female spiders are producing less mitochondrial superoxide, are better protected against oxidative attack and are then suffering less oxidative damages than males at adulthood.In tarantulas, once reaching sexual maturity, males have a life expectancy reduced to 1 to 2 years, while females can still live for 20 years, in spite of the fact that females continue to grow and moult. This study evidences an increased exposure of males to oxidative stress due to an increase in mitochondrial superoxide production and a decrease in hemolymph antioxidant defences. Such a phenomenon is likely to be part of the explanation for the sharp reduction of longevity accompanying male tarantula maturity. This opens several fundamental research roads in the future to better understand how reproduction and longevity are linked in an original ageing model

Tratamiento de las coxitis reumáticas con prótesis total cementada

Se estudia una serie de 82 prótesis totales de cadera cementadas tipo Muller implantadas en enfermos afectos de coxitis reumáticas, fundamentalmente artritis reumatoide. Los casos tienen un seguimiento medio de cuatro años y una edad media de cincuenta y un años; la mitad de ellos tenían afectados entre siete y 10 articulaciones y en la cadera el 28 por 100 presentaban protrusión acetabular. En el postoperatorio consta un 2,5 por 100 de complicación séptica y 2,5 por 100 de tromboembolismos. El análisis clínico de los resultados se basa en el dolor, la movilidad y la marcha según el baremo de Merle d'Aubigne y en la capacidad funcional segiin los criterios de STEINBROCKER. En grupo aparte se ha estudiado el resultado en los casos con un seguimiento mínimo de cinco años, en los que tenían dolor importante y en los que presentaban protrusión. En conjunto obtienen resultado muy bueno el 52,5 por 100 y bueno o aceptable el 30 por 100. El aflojamiento aumenta con el paso del tiempo y es del 18 por 100 en la serie global, pero alcanza al 30 por 100 en los casos con seguimiento de cinco años o más y las profusiones. El resultado funcional depende de las varias intervenciones practicadas en las extremidades y con el programa quirúrgico complejo conseguimos que algo más de la mitad de los enfermos recuperen una autonomía para la vida diaria fuera de su casa

Espondilitis piógenas del adulto. Análisis de 15 casos

La espondilitis piógena es una entidad clínica poco frecuente que últimamente ha experimentado un considerable aumento, relacionado con la adicción a drogas por vía parenteral. Se presentan 15 casos tratados en el período entre 1981-1988. La etiología más frecuente fue el estafilococo dorado (53%), seguida de gérmenes gramnegativos (47%). Es de destacar la presencia de factores predisponentes en un 47% de pacientes. El cuadro clínico consistió en una raquialgia acompañada de fiebre en el 73% de los casos. La radiología era normal en las etapas iniciales, pero no la gammagrafía con Ga y Te. El tratamiento fue inicialmente conservador, estando indicada la cirugía cuando se presentaron alteraciones neurológicas, abscesos paravertabrales o imposibilidad diagnóstica. En la serie presentada, 4 de los J5 pacientes fueron sometidos a tratamiento quirúrgic

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Black holes, gravitational waves and fundamental physics: a roadmap

The grand challenges of contemporary fundamental physics—dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem—all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons, singularities and ergoregions. The hitherto invisible landscape of the gravitational Universe is being unveiled before our eyes: the historical direct detection of gravitational waves by the LIGO-Virgo collaboration marks the dawn of a new era of scientific exploration. Gravitational-wave astronomy will allow us to test models of black hole formation, growth and evolution, as well as models of gravitational-wave generation and propagation. It will provide evidence for event horizons and ergoregions, test the theory of General Relativity itself, and may reveal the existence of new fundamental fields. The synthesis of these results has the potential to radically reshape our understanding of the cosmos and of the laws of Nature. The purpose of this work is to present a concise, yet comprehensive overview of the state of the art in the relevant fields of research, summarize important open problems, and lay out a roadmap for future progress. This write-up is an initiative taken within the framework of the European Action on 'Black holes, Gravitational waves and Fundamental Physics'